It is also not known if monolaurin interacts with any medications. The effects of contamination are often widespread and costly: from clinical treatment infections to outbreaks like salmonella and recurring fungal infection [Ref #38]. Nasser R, Stephen AM, Goh YK, Clandinin MT. One teaspoon of our monolaurin has3,000 mg! Monolaurin benefits from a number of clinical studies which explore the potential inhibitory effects against bacterial infections such as Borrelia burgdorferi and Borrelia garinii (which are known to cause Lyme Disease), Candida albicans (which can cause yeast infections), H. Pylori or Helicobacter Pylori (which causes Gastritis), C. difficile, Giardia lamblia, and Entamoeba histolytica (which can cause diarrhea) in lab settings. 1977 Sep;12(9):753-9. Last medically reviewed on August 22, 2017. Enhanced Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. International Journal of Antimicrobial Agents. Some people see a benefit from a single 600mg capsule per day, while others may take upwards of 3-5 grams. muscle pain. Our website services, content, and products are for informational purposes only. Monolaurin purportedly works by binding to the lipid-protein envelope of the virus, thereby preventing it from attaching and entering host cells, making infection and replication impossible [Ref #2]. Align your health hacks with your genes for optimal health & cognitive function. Based on the qualities mentioned above, monolaurin has several suggested uses. If untreated, they can eventually lead to vision loss. Monolaurin occurs naturally in mother's breast milk and is manufactured for commercial use from coconut oil or palm kernel oil. Several fungi, yeasts, and protozoa are reported to be inactivated or killed by monolaurin, including some species of ringworm and candida albicans. MAXIMUM DOSAGE Adults 3 drops/day/affected eye 0.1%, 0.15%, or 0.2% ophthalmic solution; 4 drops/day/affected eye 0.025% ophthalmic solution; 1 application/day topically brimonidine gel. As the risks associated with monolaurin ingestion are low, there are few downsides to including natural monolaurin in your diet. What kind of dosage should I be taking? Pharmacological effects of coconut oil vs. monoglycerides. Coconut oil is made up of about 50% lauric acid [4, 58]. "Here, we describe how dietary medium chain triglycerides (MCT), previously found to promote lipid catabolism, energy expenditure and weight loss, can ameliorate metabolic health via their capacity to improve both intestinal ecosystem and permeability. Volume 20, Issue 4, October 2002, Pages 258262, Sun CQ, OConnor CJ, Roberton AM. Journal of Food Safety 4:1-12 (1982), Goc, A., Niedzwiecki, A. and Rath, M. (2015), In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii. pet is about 1/8 of an adult person, so 1/8 the dosage. Some scientists believe it might help fight microbes, but human studies havent been carried out. She is a strong advocate of integrating scientific knowledge and holistic medicine. At present, anecdotal evidence suggests that monolaurin supplements or lauric acid from coconut oil may help prevent or treat some health conditions. Researchers hope that one day monolaurin could be used to create a new antibiotic or antiviral medication thats effective against a broad spectrum of microbes. The richest food source of lauric acid is coconut oil (up to 50% lauric acid). (2007). Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals. Monolaurin possesses anti-viral activity against several Viruses that reside in cell membranes (it prevents their entry into cell membranes). (2015). 2005-2023 Healthline Media a Red Ventures Company. without the wasted fillers and materials in capsules. Seems to be subjective case to case. Its antimicrobial properties have been clearly established, but more research is needed to test the effects of monolaurin on living subjects. Monolaurin has been listed as "Generally Regarded As Safe" by the FDA [Ref #15], stating "In accordance with 184.1(b)(1), the ingredient is used in food with no limitation other than current good manufacturing practice. were baicalein and monolaurin. Much later, Michigan State University researchersdiscovered what happened when we eat coconut. H. Pylori (Helicobacter Pylori) is bacteria which infects the stomach and gut and can cause complications like Gastritis or even Gastro-Esophageal Reflux Disease (GERD). WebThen you can increase the dosage to normal after that. Learn more about Digestive Health and Monolaurin. 2014 Apr 1; 306(7):E838-47. Manohar, V., Echard, B., Perricone, N., Ingram, C., Enig, M., Bagchi, D., Preuss, H. G. (2013, June). Children:Adjust to the childs weight vs. an adult. Your body can convert lauric acid into monolaurin. There are many anecdotal reports of monolaurin helping combat the flu. Although none of the insulin products available for use in dogs and cats have canine- or feline-specific amino acid sequences, anti-insulin antibodies do not appear to cause a significant clinical problem. Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus. Geriatric It is also used to treat chronic fatigue syndrome (CFS) and to boost the immune system. 2015;119(6):1561-1572. doi:10.1111/jam.12970. WebGlargine (Lantus), q 12 hr based on the estimated ideal body weight of the cat and BG levels: 0.5 U/kg q 12 hr if BG > 360 mg/dL Or 0.25 U/kg q 12 hr if BG < 360 mg/dL. It takes the body between 2 and 6 months to develop enough antibodies against FIV to be detected, so if a cat had been infected very recently, it may test An Antibacterial Skin Spray that contains the same monolaurin as well as Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. We believe that the most accurate information is found directly in the scientific source. Its used as a supplement, but no clinical studies on its health effects have been published to date. It is a safe extract, which can be taken long term. Monolaurin hasnt been evaluated by the U.S. Food and Drug Administration (FDA) as a treatment for any medical condition, so there are no standard dosing guidelines. Do not consider user experiences as medical advice. WebTreatment is given for 5 to 7 days and is not safe for pregnant cats. Monolaurin was also determined using absolute quantification: the analysis reported an average concentration of 0.28 0.24 ug/mL in the protected subjects, while the concentration was lower (0. After much research, scientistsdetermined the key to their diet was the coconut. One doctor and author, Dr. Richard Horowitz, whose clinic has treated over 12,000 patients over the past 26 years wrote about Monolaurin in his 2017 book: "Monolaurin, a coconut oil extract, has also recently been shown to have the ability to significantly affect three morphological forms of Borrelia burgdoferi and Borrelia garinii: spirochetes, latent round body forms, and borrelia biofilms, while simultaneously deceasing yeast overgrowth in the GI tract." Horowitz, Richard. Read more about Monolaurin and the Herxheimer (Die off) Reaction. Isaacs CE. The Pharmacological Effect of Lipids. Note that each number in parentheses [1, 2, 3, etc.] Pets:Also adjust based on a human adult weight. American Society for Microbiology 9 February 1998. SelfDecode does not treat, diagnose or cure any conditions, Capsules. Kabara JJ. A 20 lb. FEMS Immunology and Medical Microbiology 36 (2003) p 9-17. Breaking down the coconut oil controversy. At Inspired Nutrition, we have taken those results one step further by increasing the ratio that lauric acid is converted into monolaurin from 3% to 95%. WebDosage must be individualized. Allegedly, it also helps with skin conditions, strengthens the immune system, and balances bacteria in the gut. She loves communicating science and empowering people to achieve their optimal health. He recommends high doses that would be unattainable with coconut oil or other foods. Web. Lipids. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. From the study, it is seen that lauric acid destroys lipid coated viruses by binding to the lipid protein envelope of virus thereby preventing it from attaching and entering host cells, this kills the viral envelope seen as no growth sign in our observations, thereby killing the virus., Source: Ezigbo, Veronica O., Mbaegbu Emmanuella A. Breast milk not only provides excellent nutritional value, it also plays a very important role in protecting and supporting the immune function of infants though its healthy fat content [Ref #29]. Heres What the Experts Say About Coconut Oil, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 5 Science-Based Benefits of 5-HTP (Plus Dosage and Side Effects), The 15 Best Vitamin Brands of 2023: A Dietitians Picks, Red Raspberry Leaf Tea: Pregnancy, Benefits, and Side Effects, cow and goat milk containing small percentages of lauric acid. However, if handled carefully and stored in the refrigerator, the Task Force is comfortable using insulins beyond the date of expiration (up to 36 mo) as long as they are not discolored, flocculent, or have any change in consistency. Monolaurin has potential antibacterial effects in vitro and in vivo against several bacteria (both Gram Positive and Gram Negative) including Staphylococus aureus (Staph, MRSA), yeast, and protozoa by purportedly disintegrating the cell membrane and blocking signal transduction. We were the first to emulsify monolaurin to create high quality topical blends with the addition of powerful nutrients such ascolloidal silver,phospholipids,plantessential oilsand more. To get the upper dosage suggested by Kabara (9g monolaurin), one would need to consume about 22 tablespoons of coconut oil in a day, which is unreasonable. Furthermore, monolaurin has been shown to possess additive benefits, meaning when monolaurin is combined with other compounds health benefits are also increased [Ref # 20, 21]. Excipient (Natural vs. The dose can be increased to 3.0 grams once or twice daily thereafter. The recommended dose is one drop of ALPHAGAN P (brimonidine tartrate) in the affected eye (s) three times daily, approximately 8 hours apart. WebThe general recommended adult dose of monolaurin is 13 g. Higher amounts can be used to achieve desired results if necessary. Learn what studies have to say about its ability to combat conditions from acne to. I ordered some l-lysine and monolaurin (lauricidin) figuring Id give them a shot. 1972; 2(1):23-28. doi:10.1128/aac.2.1.23, "Glycerol monolaurate (GML) inhibits the expression of virulence factors in Staphylococus aureus and the induction of vancomycin resistance in Enterococcus faecalis, presumably by blocking signal transduction", Source: Ruzin A, Novick RP. Capsules: Capsules offer are precise dosage, are easy to transport, ensure complete digestion in the stomach and intestine, and come in either animal gelatin or vegetable cellulose formulas for those with vegetarian considerations. There may be side effects of monolaurin supplements since those are a concentrated source. Speak with your doctor before supplementing. We avoid using tertiary references. There is no valid evidence to back them up. In bacteria, monolaurin combined with monocaprin, lauric acid, or monomyristin had better results against Staphylococcus aureus [36]. Read more about Taking too much Monolaurin. Antibacterial actions of fatty acids and monoglycerides against Helicobacter pylori. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Complementary Medicine / Alternative Medicine, https://www.ncbi.nlm.nih.gov/pubmed/17966176, https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1093/nutrit/nuw002, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461171/, http://online.liebertpub.com/doi/abs/10.1089/act.2006.12.310, https://www.ncbi.nlm.nih.gov/pubmed/23767861, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924139/, https://www.ncbi.nlm.nih.gov/pubmed/19895490. Coconut oil contains around 40 to 50% of the medium chain fatty acid lauric acid, which when found on food labels is typically represented as C12. In contrast to this general finding, monolaurin was able to inhibit the growth of both gram-positive and gram-negative bacteria in skin cells [6]. You can take monolaurin on an empty stomach, however those with sensitive stomachs should take monolaurin with food as the supplement has a natural "soapy" taste which may be unpleasant to some. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Another study in the Journal of Drugs in Dermatology suggested that monolaurin extracts may be potent against several bacterial species that can cause skin infections, including Staphylococcus aureus and Streptococcus spp, when studied in lab settings. Dietary supplements are not regulated, so beware of unfamiliar additives. Eating 40 grams (about 3 tablespoons) of coconut oil has been shown to increase lauric acid in the milk of a nursing mother from 3.9% to 9.6% after 14 hours. The richest food source of lauric acid is coconut oil, with certain coconut products consisting of nearly 50 percent lauric acid. Last updated on Aug 22, 2022. But for now, theres little downside to taking a monolaurin supplement. People can also take it as a dietary supplement. You should not take so much monolaurin that you feel unwell (upset stomach, diarrhea, headache, etc.). Haase AT, et al. (2014). Read on to find out and be ready for a few surprising drawbacks of using monolaurin regularly. Monolaurin is used in the food production and cosmetics industries and is also taken as a dietary supplement. Other studies suggest that monolaurin disintegrates the protective viral envelope, killing the virus [Ref #13]. Craig-Schmidt MC, Weete JD, Faircloth SA, Wickwire MA, Livant EJ. Commonly used in dogs; injection pens (in either 0.5 U or 1 U increments) available for dogs and cats. Monolaurin may become an interesting supplement in this case. While this may not be necessary or common, it should not be harmful. This blend also harnesses the power of spearmint, rose and lemon balm essential oils. The high activity of monoglycerides against H. pylori suggests that they may be useful as active ingredients in pharmaceutical formulations. These are conditions characterised by increased intra-ocular pressure (increased pressure within your eyeballs) due to an imbalance in the production and drainage of the fluid in your eyes. So far, its effects have only been seen when tested in laboratories or on animals. A replenishing 1000 IU of Through the addition of our exclusive Monolaurin Plus, we offer a fuller spectrum of the coconut monoglycerides than other forms of monolaurin currently in the market. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. 2016. I give one 300-milligram capsule once an hour for eight doses, emptied out and mixed with water and given with an eyedropper. Do not use more than 4-times daily. Natural supplements your brain will love! Some literature goes as far as suggesting a dosage of 3-9 grams per day is needed, which equates to upwards of 15 capsules of 600mg [Ref #14]. Novel antibacterial activity of monolaurin compared with conventional antibiotics against organisms from skin infections: An in vitro study. A cell study compared monolaurin and 6 common antibiotics (including penicillin, oxacillin, and vancomycin) against bacteria causing skin infections. Monolaurin should not be used for any of the conditions described below due to the complete lack of safety and efficacy data in humans. Here are 5 potential benefits of 5-HTP, Ritual is a subscription-based vitamin company that offers protein powders and multivitamins for people of all ages. However, as the FDA do not monitor supplements, the risks can increase when using processed supplements. Many bacteria and viruses can develop resistance to antibiotic or antiviral drugs over time. While individually these additives may provide some benefit, they may also interfere with the monolaurin delivery. This might indicate that the presence of fatty acid and phenyl groups is important for comprehensive antibacterial activity. A range of vegan protein powders is available for people who wish to increase their protein intake but follow a plant-based diet. When you buy monolaurin, always look for: desiccant pack, cotton pack, foil safety seal, protective neckband, Lot # and Expiration Date. However, clinical studies are lacking [12, 13, 11, 14]. Monolaurin is made from extracting the lauric acid from coconut oil either by enzymatic hydrolysis, centrifugation, and distillation [Ref #7] or the combination of cold pressed coconut oil with purified glycerol via a shaking incubator [Ref #8]. Equivalence of lauric acid and glycerol monolaurate as inhibitors of signal transduction in Staphylococcus aureus. The level can be Under 130 pounds: 1 scoop, 2 times daily. They also caused disintegration of the plasma membranes of tissue culture cells resulting in cell lysis and death.". Antibacterial interactions of monolaurin with commonly used antimicrobials and food components [Abstract]. It is made from coconut or palm kernel oil, but also found naturally in mothers breast milk. Monolaurin should be taken alongside healthy lifestyle changes (such as adequate sleep, regular exercise, and better eating habits), and under the direction of a healthcare professional. 12(6): 310-314. No dosing guidelines can be established [38]. Skin Defense - Spray lotion for your skin Foaming Hand Soap - Soap without alcohol or Tricolosan C-A-Y Defense - Lightweight skin cream for topical use Scalp Defense - Conditioner for scalp and skin for use by humans and pets, OurUltraLaurinisconcentrated in easy to take pellets andwithout the wasted fillers and materials in capsules. Haase, A. T., Rakasz, E., Schultz-Darken, N., Nephew, K., Weisgrau, K. L., Reilly, C. S., Schlievert, P. M. (2015, June 9). All quotes below are taken directly (verbatim) from published studies and are not the opinion of this site. It was also researched against the swine flu and Herpes varicella-zoster virus (causing chickenpox and reactivating to cause shingles), which has a fat envelope. Cat multiple dose safety study: In a multiple dose safety study, 5 groups of 6 healthy cats (half male, half female) were administered ALFAXAN at 0 (saline), 5, 15 and From there, he suggests they work their way up to 3000 mg, two to three times per day. Learn more here. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. ALPHAGAN P ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. The antimicrobial function of milk lipids. Monolaurin has been shown in some lab studies to not contribute to bacteria resistance. WebDescription. Serving Size: 1 scoop(1 tsp., about 80 pellets) = 3,000 mg. Other Ingredients: Glycerol. Monolaurin's potential immune supporting properties may act as a biofilm disruptor in this layer [Ref #39], but its clinical application has not been proven. Coconut oil is safe unless you have a coconut allergy or consume it in very large amounts [54, 8]. Packaging Features (Safety and Quality Control Measures): An important but often overlooked component of supplements are the physical packaging and safety features put in place. Simple tip - Tilting the head forward helps swallowing, tilting head back makes swallowing more difficult. ii) ", Source: Bergsson G, Steingrmsson O, Thormar H. Bactericidal effects of fatty acids and monoglycerides on Helicobacter pylori. The affirmation of this ingredient as generally recognized as safe (GRAS) as a direct human food ingredient" However, the FDA does not elaborate on any daily maximums. Monolaurin was active against the bacteria (Borrelia burgdorferi) that causes Lyme disease in dishes. Monolaurin is found in coconut oil, which is an edible, non-toxic, and a standard cooking oil. Check out the products in the Product Locator. Enjoyonlinesavings! "In the presence of Monolaurin monolaurate had the highest bactericidal activity against E. coli and other Gram-negative bacteria It may be concluded from various experimental results that the transport of monolaurin into the cell membrane of E. coli was stimulated by the action of citric or polyphosphoric acid", Source: Kabara JJ. Supplements are available in capsule, pellets and powder. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. People with intestinal inflammation or risk of multiple sclerosis may need to limit their consumption of coconut and MCT oil, and, therefore monolaurin [57]. Monolaurin and the Herxheimer (Die off) Reaction. https://www.nhs.uk/conditions/leaky-gut-syndrome/. Antibiotics may just make things worse for you. http://aocs.files.cms-plus.com/inform/2005/6/p386-387.pdf, Ruzin A, Novick RP. Despite this, evidence suggests that the compound may have the following qualities: Monolaurin shows antibacterial effects against a range of bacteria including antibiotic-resistant bacteria called Staphylococcus aureus (Staph). If adverse effects occur, they stop taking monolaurin for a day or two to give their body a little extra time to remove the dead organisms. Then they start again at a lower dosage and gradually increase, until their body can handle it. This approach remains completely unproven [56]. Herbs and nutrients to keep things flowing. Since monolaurin is the same size as the fat molecule of the virus, it absorbs into the cells fat layer. Dosage form: ophthalmic solution Lauric acid levels in breast milk can vary. WebMonolaurin is used for the common cold, flu (influenza), shingles ( herpes zoster ), and other infections, but there is no good scientific evidence to support its use. Last medically reviewed on October 2, 2017. Annals of the New York Academy of Sciences. In their study whose findings appear in the journal Frontiers in Medicine the investigators analyzed the potential of 14 different plant extracts in killing B. burgdorferi. Read the full checklist in the Monolaurin Buying Guide. This PMC. In this situation, the gut microbiome is compromised. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Monolaurin has shown antibacterial and antiviral effects when examined in test tubes and culture dishes, which is referred to as in vitro testing. Seleem, D., Chen, E., Benso, B., Pardi, V., & Murata, R. M. (2016, June 22). Some people take monolaurin as an immune booster. The study found statistically significant broad spectrum antibiotic effects without any of the resistance of common antibiotics. 1994 Feb;75 ( Pt 2):353-61. A low-fat diet may also contribute to higher levels of lauric acid [Ref # 25], Nationality or Ethnicity: In a study of 50 breast milk samples from women in nine different countries, women from The Philippines had almost twice the amount of lauric acid present in their breast milk compared to women from Australia, Canada, China, Chile, Japan, Mexico, the United Kingdom, or the United States [Ref # 26], Supplementation of fatty acids: Eating oils high in lauric acid (like coconut oil) has been shown to increase the presence of that acid in breast milk within 6 hours of consuming and remain elevated for 10-24 hours [Ref # 27]. Page 4 of 26 Children (2-18 years of age): The use of ALPHAGAN P is currently not recommended in children, as several serious adverse reactions have been reported in association with the administration of brimonidine tartrate ophthalmic solution 0.2% in pediatric population. promoting collagen growth. We comply with the HONcode standard for trustworthy health information. However, experts are unsure how the body converts lauric acid into monolaurin, and at what rates. S. Rial, A. Karelis, K. Bergeron, & C. Mounier. Read more research on Monolaurin and Bacteria. Journal of Drugs in Dermatology : JDD [2007, 6(10):991-998], Ruzin A, Novick RP. The antibiotics included penicillin, oxacillin, and vancomycin. Existing research explores monolaurins potential to exhibit antiviral, antibacterial, and antifungal properties in controlled laboratory studies. DISCLAIMER: This content is for informational and educational purposes only. The study concluded that monolaurin demonstrated statistically significant in vitro broad-spectrum sensitivity against the bacteria responsible for the skin infections. Monolaurin should be avoided during pregnancy and breastfeeding due to a lack of safety data. dizziness. To stay on the safe side, people should speak to a pharmacist or doctor before taking monolaurin, especially if they are: Those taking monolaurin supplements should follow the dosing guidelines on the packet carefully. He claims that the monolaurin yield from coconut oil is no more than 3% . Monolaurin has statistically significant in vitro broad-spectrum sensitivity against Gram-positive and Gram-negative bacterial isolates from superficial skin infections. Food may also aid in the bioavailability of some supplements. AAHA suggests that veterinary professionals make every effort to use veterinary FDA-approved products and base their inventory-purchasing decisions on what product is most beneficial to the patient. (A 15 pound animal = 1/10, or 8 pellets a day.) Research suggests that monolaurin may be effective in inactivating H. Pylori, regardless of stomach pH [Ref #32]. Generic name: BRIMONIDINE TARTRATE 1mg in 1mL.
