This is a serious medical condition that, if left untreated, can lead to kidney damage. Talk with your doctor about any liver problems you may have and whether its safe for you to take Zetia. Taking Zetia with a statin may cause this side effect. In studies, muscle problems commonly occurred in adults and children who took Zetia with statin drugs. Read More. Zetia comes as a tablet that you swallow. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . The following information describes dosages that are commonly used or recommended. Ezetimibe may be used alone or with other drugs (such as "statins" or . If you and your doctor decide that Zetia treatment isnt right for you, you simply wont take any more doses. This section doesnt contain all drugs that may interact with Zetia. Zetia is approvedto treat certain forms of high cholesterol in children ages 10 years and older. When this happens, more cholesterol can then be cleared from your blood by your liver. It can develop suddenly or gradually over time. Its not known how many adults and children experienced muscle pain in clinical studies of other conditions treated with Zetia and statin drugs. Zetia can interact with several other medications. Both drugs are typically taken once each day. If you develop bothersome muscle pain or other muscle-related symptoms, talk with your doctor. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. Its a place where people with certain conditions can find support and connect with others. Its not known if Zetia is safe to take during pregnancy. Zetia and Crestor are both brand-name drugs. For more information, see the How Zetia works section below. Brain fog. What causes POTS? Common sweetener erythritol tied to higher risk of stroke and heart attack, Gout: How metabolic syndrome may increase the risk, A new therapeutic target for the prevention of heart failure due to aortic stenosis, Skipping breakfast and fasting may compromise the immune system, Leqvio side effects: What you should know, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, 2.4% of people who took a statin drug alone, 2.5% of people who took Zetia with a statin drug, 2.2% of people who took a statin drug alone, 3.2% of adults and children who took Zetia with a statin drug experienced muscle pain, 2.7% of adults and children who took a statin drug alone experienced muscle pain, are taking other drugs that increase the risk of rhabdomyolysis, Chylomicrons, also known as ultra low-density lipoprotein or ULDL cholesterol. Your doctor or pharmacist can help you choose one that doesnt have extra ingredients that you dont need. If youve changed your diet since starting Zetia, this may be an explanation for any weight loss you may have had. If left untreated, it can cause your kidneys to stop working properly. Zetia is sometimes used with medications in the statin drug class. Medications in this class prevent your small intestine from absorbing cholesterol. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. For more information about how the drug is used, see the Zetia uses section below. Zetia is contraindicated under the following conditions: Zetia tablets should be stored at a room temperature of 77F (25C) in a tightly sealed container away from light. Each type is described below in more detail. They may be able to help determine whats causing your hair loss. Can diet help improve depression symptoms? Brand-name medications usually cost more than generics. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). And your doctor can use this information to adjust your treatment plan if needed. You likely wont notice Zetia working in your body. These side effects may be temporary, lasting a few days to weeks. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. Your doctor will likely start you on the typical dosage approved to treat your condition. Zetia may not be right for you if you have certain medical conditions or other factors affecting your health. Postural orthostatic tachycardia syndrome (POTS) is one of a group of disorders that have orthostatic intolerance (OI) as their primary symptom. Physicians who treat dysautonomia can be located on our Physician List. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). In people with POTS, more blood collects in the lower body when standing upright. The following lists contain some of the key side effects that may occur while taking Zetia. And Zetia hasnt been shown to affect blood sugar levels in clinical studies of people with diabetes and people without diabetes. However, you shouldnt stop taking Zetia without first talking with your doctor. These include: Note: For more information about the potential negative effects of Zetia, see the Zetia side effects section above. What causes POTS? Postural Orthostatic Tachycardia Syndrome (POTS) is a blood flow disorder that causes a sudden spike in heartbeat with no change in blood pressure when going from a horizontal or seated to a standing position. Porphyrias are rare, mainly genetic disorders that affect the body's ability to make hemoglobin. Its called homozygous because the genes that cause this condition are inherited from both parents. Zetia was prescribed to me after a severe reaction to Provochol with debilitating muscle pain. However, if the side effects last longer than . However, 0.5% of adults and children who took Zetia with a statin drug experienced muscle pain so bothersome that they had to stop treatment. You may also want to check out the online communities at Bezzy. This is because large meals can cause blood to pool excessively in the abdomen. The only FDA-approved dosage of Zetia for children is 10 mg once a day. Here we look at how Zetia and Lipitor are alike and different. Cholesterol is made naturally in your liver. (For information on side effects, see the Zetia side effects section above.). Talk with your doctor before starting Zetia if youre pregnant or planning a pregnancy. But some people have reported memory loss, confusion, and forgetfulness while taking a statin drug. Use of the terms male and female in this article refers to sex assigned at birth. It can develop suddenly or maybe over time. Some people witness mild symptoms, some have a big impact on their lives due . . In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. Your doctor may do liver function tests before you start treatment and regularly during your Zetia treatment. Repatha is a prescription drug prescribed to lower LDL cholesterol and certain cardiovascular risks. It also isnt known how many adults and children experienced joint pain in clinical studies of Zetia used to treat other conditions. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. Our website services, content, and products are for informational purposes only. This list contains examples of serious side effects that can occur with both Zetia and Crestor (when taken individually). If youre experiencing hair loss while using Zetia, talk with your doctor. If your cholesterol levels havent started to improve, they may recommend a different treatment for you. It is created by eHealthMe based on reports of 45,364 people who have side effects when taking Zetia from the FDA, and is updated regularly. Its not clear if CoQ10 prevents muscle-related side effects when Zetia is taken with a statin, but it might help. Dizziness is a rare side effect of taking Zetia. Like most drugs, Zetia can cause an allergic reaction in some people. For more information on these side effects, see Side effect details below. Total cholesterol levels were reduced by an average of: LDL (bad) cholesterol levels were reduced by an average of: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition caused by a mutation (change) in the genes that control how cholesterol is cleared from your body. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. Then theyll monitor whether the drug is working for you and whether you experience any side effects. Use these discussion points about familial hypercholesterolemia to prepare for your doctors appointment. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. Others may experience GI issues in conjunction with other symptoms, such as fainting. In clinical studies, Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). However, animal studies dont always predict what will happen in humans. Tell them about all prescription, over-the-counter, and other drugs you take. As with most drugs, some people can have an allergic reaction after taking Zetia. Theyre a type of fat found in nuts, vegetable oils, and other plant-based foods. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Zetia. tightness of chest or wheezing. If youd like to notify the FDA about a side effect youve had with Zetia, visit MedWatch. The heart beats faster to pump it up to the brain, but with little success. However, you may need to avoid grapefruit if you take Zetia with a statin, another type of cholesterol medication. Your doctor may stop your Zetia treatment if it isnt safe or effective for you. Phase IV trials are used to detect adverse drug . Doing this can raise your risk of side effects. What Are the Injectable Alternatives to Statins? Dont take an extra dose to make up for your missed dose. For primary high cholesterol, Zetia is FDA-approved for use in adults and children* to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet. Symptoms: This section is currently in development. Zetia does not cause an increase or a decrease in blood pressure. If youre concerned about joint pain while using Zetia, talk with your doctor. If you develop increased liver enzyme levels, your doctor may make changes to your treatment plan. upper respiratory tract infection, including the common cold. Some people with POTS also may have one or more . If you have questions about the differences between Zetia and statin drugs, talk with your doctor. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. However, be sure to take the dosage your doctor prescribes for you. You may experience muscle problems as a side effect of Zetia. If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. Zetia is a prescription drug used to treat certain types of high cholesterol. More research is needed to know for sure. Last medically reviewed on September 18, 2021. To help make sure you dont miss a dose, try setting a reminder on your phone. Heres some detail on certain side effects this drug may or may not cause. Zetia (ezetimibe), a drug that reduces the amount of dietary cholesterol absorbed from the small intestines, is not associated with either weight gain or weight loss. POTS was also linked, to a lesser degree, to Covid vaccination with an mRNA vaccine, according to the new study. You can use the study as a second opinion to make health care decisions. Temporary excursions of 59F to 86F (15C to 30C) are allowed. Zetia is FDA-approved to treat certain types of high cholesterol in adults and in children when used with a low-cholesterol diet. Zetia can be used to treat high cholesterol or homozygous sitosterolemia (a condition that causes high fat levels) in certain people. Muscle problems were reported in clinical studies of adults and children who took Zetia with statin drugs. Zetia comes as a tablet that you swallow. If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. Most of these side effects may go away within a few days or a couple of weeks. It isnt safe to eat grapefruit or drink grapefruit juice while using statins. There are no known interactions between Zetia and alcohol. This active drug is also available as a generic medication. Learn about side effects, costs. Cholesterol is a fatty substance found in the cells of your body. Merck, the manufacturer of Zetia, offers a Patient Assistance Program. Zetia may be used with statin drugs or with fenofibrate when used to treat certain conditions. Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. This can cause Zetia to be less effective. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. Lipitor contains the active drug atorvastatin. Theyll guide you on the safest treatment options for you. Here we look at how Zetia and Crestor are alike and different. Its primary metabolic pathway is via hepatic glucuronic conjunction. There arent any herbs or supplements that have been specifically reported to interact with Zetia. You may find your symptoms are worse in the morning, and they may change from day to day. Symptoms can be mild or serious and can include: If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. You can learn more about how we ensure our content is accurate and current by reading our. Learn about side effects, dosage, and more. It also helps keep the drug from harming the environment. In clinical studies that lasted 8 weeks, Zetia was compared with a placebo (a treatment with no active drug). It can cause mild side effects and, less commonly, serious side effects. Get emergency medical help if you have signs of an allergic reaction to Zetia: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Below are medications that can interact with Zetia. If you have a history of heavy alcohol use and are taking Zetia with a statin drug, you may have a higher risk of side effects. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Lipitor, or with both drugs (when taken individually). These drugs havent been directly compared in clinical studies. Zetia is available as a tablet that you take by mouth. Zetia can cause mild or serious side effects. sinusitis. Cholesterol can also be found in foods such as eggs, cheese, and meat. And some may be easily managed, too. Also, Zetia use may cause increased liver enzyme levels, especially if its taken with a statin drug. Females who could become pregnant should use birth control while taking Zetia with a statin drug. Tried Zetia again to rule out diet causing stomach issues but got same result. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. Zetia (ezetimibe) is prescribed to lower high cholesterol in adults and some children, along with a low cholesterol diet. You may also be having a reaction to all the medications mixed together. In these groups, joint pain occurred in: The length of time that adults and children experienced joint pain while taking Zetia in these clinical studies isnt known. But keep in mind that Zetia is used to reduce cholesterol levels in your blood. It can cause mild side effects and, less commonly, serious side effects. For mixed high cholesterol, Zetia is FDA-approved to decrease levels of: For this purpose, Zetia is used with a low-cholesterol diet and is taken with other drugs. Lipitor is also FDA-approved for the following conditions when used with a low-cholesterol diet: primary dysbetalipoproteinemia in adults (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), liver complications, such as high levels of, Both Zetia and Crestor are FDA-approved to treat the following conditions* when used with a. Crestor is also FDA-approved for the following conditions in adults when used with a low-cholesterol diet: primary dysbetalipoproteinemia (a genetic condition that causes high total cholesterol, high triglycerides, and low HDL levels), pain on the right side of your body, below your ribs, in adults as monotherapy or in combination with an HMG-CoA reductase inhibitor (statin drug), in adults in combination with a fenofibrate, in combination with statins, in people with hepatic disease, in combination with statins, in people with elevated hepatic transaminases, in combination with statins, during pregnancy or in someone planning to become pregnant, in combination with statins, while breastfeeding, in people who have a known allergy to Zetia. Clinical studies for ezetimibe did not note any difference in weight in those that took the drug versus those that did not. Statins shouldnt be used during pregnancy. The causes of POTS are unknown, but the problem is thought to lie in the communication breakdown between the brain and the cardiovascular system. Allergic reaction. They may also check you for signs of muscle breakdown or kidney damage. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Zetia contains the active drug ezetimibe. Talk with your doctor about birth control options that may be best for you. Clinical studies have shown Zetia to be effective for treating homozygous familial hypercholesterolemia when used with atorvastatin or simvastatin. Zetia is FDA-approved to treat mixed high cholesterol when used with fenofibrate. Crestor is available in a generic form called rosuvastatin. This may increase your risk of side effects. While taking Zetia, tell your doctor right away if you experience extreme muscle pain, muscle tenderness, or dark-colored urine. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. Talk with your doctor or pharmacist if you have trouble swallowing Zetia tablets. POTS is a form of "autonomic dysregulation" (a nervous system disorder) in which your heart rate spikes upon standing (among other symptoms). But the condition isn't well understood, and many patients are dismissed as having anxiety, delaying diagnosis. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. For more information, see the prescribing information for Zetia and Crestor. You can also ask your pharmacist for information on how to dispose of your medication. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. This makes it difficult to keep an upright posture without abnormal heart-rate (tachycardia) and/or sympathetic activity. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Energy Drinks, such as Red Bull, should be avoided in those with POTS. Zetia is also available in a generic form called ezetimibe. Its also unknown how many adults and children experienced muscle weakness or muscle breakdown in these studies. Zetia isnt a statin drug. I am a stay at home mama to a sweet baby girl, and wife to an amazing h. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. We've provided a list of the best at-home tests for. Its also not known if the drug is safe to take while breastfeeding or whether the drug passes into breast milk. Avoid eating foods high in fat or cholesterol, or Zetia will not be as effective. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. The heartbeat increases with a feeling of the heart fluttering. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. Statins lower cholesterol by preventing your liver from making new cholesterol. They can both be taken with or without food. Both drugs are typically taken once each day. Lipitor and Zetia belong to different drug classes. Side effects could occur in children who are breastfed by someone taking a statin drug. * To learn more about this side effect, see the Side effects explained section below. Zetias effect on cardiovascular morbidity and mortality isnt known. However, side effects are generally mild and go away as the body adjusts to the medication. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. They can suggest ways to help relieve your side effects, or they may recommend a different treatment option for you. Tell your doctor if youre experiencing bothersome side effects from Zetia. However, you may still experience muscle problems if you use Zetia alone. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). Ask your doctor what other medications are better options for you. Zetia is meant to be used as a long-term treatment. These conditions can raise your risk of muscle problems while taking Zetia. Zetia contains the active drug ezetimibe. Zetia has a well-documented safety profile. Learn about the drugs dosage, forms, strengths. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. Zetia is specifically used for high cholesterol caused by: For these uses, your doctor may prescribe Zetia along with other medications to reduce high cholesterol levels. You should always consult your doctor or another healthcare professional before taking any medication. They can recommend treatments that may help with joint pain, or they may recommend a different treatment option for you. Zetia can cause certain side effects, some of which are more common than others. It wasnt reported during studies of the drug. If your muscle-related side effects dont go away or become severe, tell your doctor right away. If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. muscle pain while taking ezetimibe with a statin. Zetia hasnt been studied in certain types of dyslipidemia, including Frederickson types I, III, IV, and V. Zetia is taken orally with or without food. You should always consult your doctor or another healthcare professional before taking any medication. If youve noticed memory problems while taking Zetia, talk with your doctor. Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. This article provides several useful tips on medication disposal. POTS is a form of orthostatic intolerance that is associated with the presence of excessive tachycardia and many other symptoms upon standing. You may not have any symptoms of gallstones unless they cause your gallbladder to swell. The brand name for this drug combination is Vytorin. Learn more about the link. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. POTS is commonly associated with low levels of fluid. Then you can share this information with your doctor. (Primary hyperlipidemia is also called primary high cholesterol.) In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). A life-changing condition called POTS, which can cause fainting, irregular heartbeats and dizziness, particularly among young women, appears to be on the rise as a result of the coronavirus pandemic. But its not clear whether this side effect occurred in studies. Talk with your doctor if you have questions about managing your blood pressure or blood sugar while using Zetia. yellowing of your skin or the whites of your eyes, ahajournals.org/doi/10.1161/JAHA.118.009835, organon.com/product/usa/pi_circulars/z/zetia/zetia_pi.pdf, Alternatives to Statins for Lowering Cholesterol. Youll also need to check your insurance plan, as it may only cover one or the other. * This is a partial list of mild side effects from Zetia. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Would a lower dose of Zetia help to reduce my risk of side effects? This is especially helpful to do when you first start taking new drugs or using a combination of treatments. This can cause gallstones (hardened stones in your gallbladder). Increased liver enzymes can be a sign of liver damage. Talk with your doctor if youre concerned about your risk of memory loss while using Zetia alone or with a statin drug. They often originate at the base of the skull and spreading on the back of the head and neck. During Zetia treatment, your doctor will likely recommend blood tests. About Postural orthostatic tachycardia syndrome. Medications in the fibrate drug class are used to treat high cholesterol. If you have joint pain while taking Zetia, you may also experience swelling, redness, or weakness in your joints. Before taking Zetia, talk with your doctor and pharmacist. Read on to find out more about healthy cholesterol levels, and if a cholesterol level of 250 ml/dL is considered, Heart disease is a top cause of death in the U.S. But, they can have side effects and might not be right for you. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). 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