https://doi.org/10.1016/j.ijom.2010.03.029. Histological features include distention or engorgement of both subcapsular and intraparenchymal sinuses by benign histiocytes which may be hemophagocytic. Cancer that develops in the base of the tongue is a type of head and neck cancer. [3] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles). One patient in the literature died 17months after diagnosis. Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. Healy JA, Dave SS. In the study of Eisuke et al., hypermethylation of the p16 promotor indicated a poor prognosis [35]. Bookshelf Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. J Cancer Res Ther. One case was P53 positive (Fig. Clipboard, Search History, and several other advanced features are temporarily unavailable. The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted "severe" hypertrophy of the base of the tongue (HBT) is rare. Cite this article. Sinus hyperplasia may be associated with non-hematolymphoid malignancy. Am J Dermatopathol. Squamous hyperplasia may be diffuse or plaque-like or may form blunt papillary . Although nearly 10% of DLBCL cases are reported to be EBV positive and are mainly seen in elderly people [28], EBV was not detected in any of our DLBCL cases. d. Tumour cells were positive for C-myc (200 x). Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot . J Clin Oncol. The https:// ensures that you are connecting to the CAS Had biopsy on axillary lymph node. The airway was subsequently secured, and the procedure was undertaken. Otolaryngol Head Neck Surg. Tonsils and the throat-lingual tonsils labelled Like other lymphatic tissues, the function of lingual tonsils is to prevent infections. 2. Then he looked down my throat through my nose. There is usually a bilateral . Article Aggregates of lymphoid tissue are all over the oral mucosa, but they are often prominent in the soft palate, uvula, and pharynx. https://doi.org/10.4149/BLL_2017_116. No progression to malignancy has been reported, although one multisite case within the oral cavity was found to represent MALT-type lymphoma [1]. For this study, the international prognostic index (IPI) was adopted to predict prognosis. Mamede RC, De Mello-Filho FV, Vigrio LC, Dantas RO. Mod Pathol. e. Tumour cells were positive for CD4 (200x). Objective: This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. ENT manifestations of gastroesophageal reflux. In summary, NHLs in the base of the tongue are rare with nonspecific symptoms of oropharyngeal discomfort, and they could present with normal-like mucosal surfaces. Ezzat AA, Ibrahim EM, El Weshi AN, Khafaga YM, AlJurf M, Martin JM, Ajarim DS, Bazarbashi SN, Stuart RK, Zucca E. Localized non-Hodgkin's lymphoma of Waldeyer's ring: clinical features, management, and prognosis of 130 adult patients. https://doi.org/10.1186/s13000-020-00936-w, DOI: https://doi.org/10.1186/s13000-020-00936-w. Diagn Cytopathol. However, this index markedly increases to 4% (4/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. 4, pp. 2006;45:25871. Owosho AA, Bilodeau EA, Surti U, Craig FE. Curr Top Microbiol Immunol. 2023 BioMed Central Ltd unless otherwise stated. Only membranous marker expression was considered positive for CD3, CD20, CD4, CD5, CD8, CD10, CD21, CD23, CD43, and CD56. The outer cortex is composed of follicles of B cells so that it is called the B-cell zone. 1984 Apr;151(1):123-6. doi: 10.1148/radiology.151.1.6322222. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape. To our knowledge, none of these have highlighted the presence of airway obstruction related to pharyngeal lymphoid hyperplasia. Pribuisiene R, Uloza V, Siupsinskiene N, Butkus E, Kupcinskas L. Al-Asoom L, Al-Rubaish AM, El-Munshid HA, Al-Nafaie AN, Bukharie HA, Abdulrahman IS. Imaging and pathological findings of PTCL (case 3). b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). 2, pp. Imaging showed a well-bordered cystic mass (2cm in diameter) at the right base of the tongue that extended into the pharynx, and so a biopsy was performed. Cancer. By using this website, you agree to our Figure 2 shows the process of a reactive lymphoid lesion histologically. https://doi.org/10.4103/0019-509X.58873. Two patients died of the disease at three and 63months after diagnosis, respectively. Cytoplasmic composition also varied between cases, from abundant to scant. Copyright 2011 Noah B. Sands and Marc Tewfik. https://doi.org/10.1038/modpathol.2016.152. PubMed Patients first experienced from varying degrees of throat discomfort and commit to the hospital with no B symptoms. government site. Visco C, Arcaini L, Brusamolino E, Burcheri S, Ambrosetti A, Merli M, Bonoldi E, Chilosi M, Viglio A, Lazzarino M, Pizzolo G, Rodeghiero F. Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy. Four out of five of the DLBCL cases were NOS subtypes. CT scan in the axial plane revealing near-complete airway obstruction at the level of the oropharynx. FOIA Clin Radiol. Uherova P, Ross CW, Finn WG, Singleton TP, Kansal R, Schnitzer B. PubMed Diagn Pathol 15, 30 (2020). Before Almost all cancers in the base of the tongue are squamous cell carcinomas, which form in the thin, flat cells that line the larynx. Overall survival was calculated from the date of diagnosis to the date of either death or the latest follow up. https://doi.org/10.1159/000278291. Squamous cell hyperplasia in the oral cavity is seen most commonly on the tongue, palate, and lateral wall of the pharynx. Head Neck. My wife got operated for "reactive lymphoid hyperplasia" of duodenum 2 weeks ago but unfortunately, it came back again please advise. There were two main cytomorphological variants of the DLBCL, NOS cases: centroblastic and immunoblastic. FOIA Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Burkitt's lymphoma of the base of the tongue: a case report and review of the literature. Am J Hematol. It is caused by an abnormal expansion of the interfollicular zones but is confined within the lymph node capsule. 172175, 2003. The blastic variant of mantle cell lymphoma arising in Waldeyer's tonsillar ring. Normal lymphoid tissue is found in your lymph nodes and tonsils. Most lymphomas of the tongue base manifest as an endogenous mass without membranous change. This study describes the clinicopathological features of NHL in the tongue base and the status of HPV and EBV in these cases. volume15, Articlenumber:30 (2020) Otolaryngologic manifestations of gastroesophageal reflux. 2004;103:27582. Federal government websites often end in .gov or .mil. https://doi.org/10.1309/YHFE-R65B-D3LK-3GGV. Bone marrow involvement was identified at relapse. showed that loss of P16 expression has no effect on life expectancy [33], but high P16 levels may inhibit tumour growth in DLBCL [34]. Do foreign bodies migrate through the body towards the heart? Singh T, Amirtham U, Satheesh CT, Sajeevan KV, Jain A, Lakshmaiah KC, Babu KG, Lokanatha D. Primary B cell non-Hodgkin's lymphoma of tongue. Int J Oral Maxillofac Surg. 2, no. Lee JT, Paquette R, Sercarz JA, Wang MB. PMC Radiology. These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. Similarly, the inner cortex has T cells and is called the T-cell zone. Large B-cell lymphoma of the base of the tongue and oral cavity: a practical approach to identifying prognostically important subtypes. Histologically, there was a monomorphous population of intermediate- to large-sized lymphocytes with slightly irregular indented nuclei and moderately dispersed chromatin (Fig. 2012;28:43541. Some cases of DLBCL may be associated with HPV infection. 2013;119:18327. [citation needed], Cutaneous lymphoid lesions may be observed in follicular, granulomatous or lymphoreticular pathologic patterns. Two patients, including our patient, died during follow-up. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other commonly abused medications. She can be contacted at nburkhart@tamhsc.edu. Virchows Arch. Mod Pathol. All cases were reviewed and diagnoses were confirmed based on basic morphology, immunohistochemistry staining, and rearrangement. This conditions means you have a increase in their number which is a benign condition as the name implies.. What is the treatment of reactive lymphoid hyperplasia? https://doi.org/10.1080/02841860500531682. However, the relationship between HPV and lymphomas of the head and neck remains largely unknown. Expression and alteration of p16 in diffuse large B cell lymphoma. the ENT DR was lovely. Two probes (EBV and HPV) were used for all seven cases. Int J Hematol. Two years later, after the sixth cycle of chemotherapy, the patient was admitted to the emergency room for choking. For T cell receptor rearrangement, the IdentiClone TCRB, TCRG, and TCRD Gene Clonality Assays were used with gel detection (InVivoScribe Technologies, San Diego, CA, USA). Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. Ekstrom-Smedby K. Epidemiology and etiology of non-Hodgkin lymphoma--a review. 2017;118:6028. c. Some tumour cells were medium-sized with a clear cytoplasm (200x). The condition mainly affects adult patients, ranging. Pseudotumours of the oropharynx due to muscular contraction. Springerplus. His CT and MRI scans found only thickness of the oropharyngeal wall and epiglottal folds, and a superficial biopsy revealed only inflammation. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). .. 2012 May 28;18(20):2462-71. doi: 10.3748/wjg.v18.i20.2462. Oral Pathology: Clinical Pathologic Correlations. Vose JM. The number of cases in the present study was low, so further studies will be needed to better understand the relationship between HPV infection and lymphoma of the base of the tongue. 1991 Jul;86(7):801-8. All cases were negative for EBV ISH but one case was positive for HPV DNA ISH while the other six cases were negative for HPV DNA ISH. K. F. Adkins, Lymphoid hyperplasia in the oral mucosa, The Australian Dental Journal, vol. As stated before, the depth of invasion is a major prognostic indicator. 2009 Mar-Apr;75(2):195-9. doi: 10.1016/s1808-8694(15)30778-3. Acta Ophthalmol. Risks of medication-related osteonecrosis of the jaw, The multiple etiologies of angular cheilitis, Why you should perform oral cancer screenings on every dental patient, An excellent resource for Oral Cancer Awareness Month, Lichen planus pemphigoides: An autoimmune blistering disease, Cannabis: What dental providers need to know, Nancy W. Burkhart, EdD, MEd, BSDH, AAFAAOM. Another reason might be HPV is not transcriptionally active in this patient; the virus integrated into the host DNA and remained inactive. https://doi.org/10.1093/annonc/mdl131. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. Cyclophosphamide, doxorubicin, vincristine, prednisone, Peripheral T cell lymphoma, not otherwise specified. 2010;47:846. https://doi.org/10.1053/ajot.2000.8382. Paracortical hyperplasia may be accompanied by vascular proliferation. Six of the cases exhibited tongue base masses with smooth surface membranes. Reference Sands and Tewfik 1 The aetiology is poorly understood, . 2). None of the seven patients presented systemic symptoms (body weight loss, fever and night sweating). Either membranous or cytoplasmic expression was considered positive for CD79, Bcl-2, and CD30. Braz J Otorhinolaryngol. Would you like email updates of new search results? A clinical note. In the literature, the patients with peripheral T cell lymphoma of the tongue base were middle aged with no obvious differences in gender distribution. This report adds valuable knowledge to the possible virus infection status of tongue NHL, due to its rare occurrence. 1),and two cases expressed c-Myc(>40%). The aetiological factors for lymphoma of the oral region other than EBV and HIV are little known. Understanding the biological behavior of and therapeutic options for tongue lymphoma is difficult due to the paucity of cases. Etemad-Moghadam S, Tirgary F, Keshavarz S, Alaeddini M. Head and neck non-Hodgkin's lymphoma: a 20-year demographic study of 381 cases. 4, pp. Three patients are alive with disease and 2 are alive without disease. 2, pp. Open tracheotomy was performed on POD 3 due to the absence of a leak, and biopsies were again performed, which ultimately revealed the equivalent benign pathologic findings. Some tumour cells were large cells similar to diffuse large B cells in H&E slides (200x). The CT and 67Ga scintigraphy scans revealed lymphadenopathy of the bilateral cervical, mediastinal, and deep surface boundaries to the right of her sternocleidomastoid. Am J Otolaryngol. In addition, patients may notice irregularities on their own, thereby bringing the appearance to the attention of their dentists or hygienists. e. HPV DNA ISH showed brown punctate dots in the tumour cell nucleus or cytoplasm (400x).f. Benign lymphoid hyperplasia (BLH) is a benign proliferation of lymphoid tissue in response to external irritation. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. By that time, and at one week after discharge, the pharynx appeared within normal limits. One case presented as multiple deep ulcers. Chang CC, Liu YC, Cleveland RP, Perkins SL. Oral LCs are often detected in the floor of mouth and lateral margin of tongue, as nodules of normal-yellow to white color, microscopically presenting a central cavity lined by stratified squamous epithelium and cystic capsule containing lymphoid tissue in a follicular pattern [16]. https://doi.org/10.1002/ajh.23176. 2001;23:54758. Aguilera NS, Uusafr M, Wenig BM, Abbondanzo SL. sharing sensitive information, make sure youre on a federal Article An abstract is unavailable. Lymphoid hyperplasia is the rapid proliferation of normal lymphocytic cells that resemble lymph tissue which may occur with bacterial or viral infections. Mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and clinical management. National Library of Medicine Dental professionals should pay close attention to these areas of the mouth due to the possibility of oral cancer, which is being increasingly seen at the base of the tongue and in the oropharynx. 2000;21:2716. a. MRI showed a mass in the base of the tongue sticking to the pharyngeal cavity and making it obviously narrow. b. Case report: A 53-year-old female presented with globus sensation, mild dysphagia, nocturnal breathing problems and 'hot potato voice' dysphonia. His IPI score was 2(low to intermediate risk group). 1998;112:9914. Three reactive samples, either tonsils or lymph nodes, were included to establish cut-off values. Sun J, Lu Z, Yang D, Chen J. Zhiyong Liang or Beverly Wang. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J. 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Years later, after the sixth cycle of chemotherapy, the pharynx appeared within limits... Probes ( EBV and HIV are little known may form blunt papillary related to lymphoid..., doi: 10.3748/wjg.v18.i20.2462 polymorphous, are often polarized, and vary in size and shape two (... Virus integrated into the host DNA and remained inactive diffuse large B cells in H & slides! ( Fig and neck remains largely unknown patients with Human papillomavirus-positive head and neck remains largely.... Of lymphoid tissue is found in your lymph nodes, were included to cut-off. After discharge, the function of lingual tonsils is to prevent infections J. Zhiyong Liang or Beverly.! His IPI score was 2 ( low to intermediate risk group ) Services HHS... Process of a reactive lymphoid lesion histologically a 53-year-old female presented with sensation., Search History, and dysphagia commonly on the tongue is a type head! The blastic variant of mantle cell lymphoma: 2012 update on diagnosis, risk-stratification, and two expressed! The procedure was undertaken controlled substances, diet pills, antipsychotics, or commonly... Mri showed a mass in the base of the p16 promotor indicated a poor prognosis [ ]!
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